Past research projects

Browse through all the research projects supported by AOCMF
  • Anti-osteoclastic drugs and their impact on maxillofacial and orthopedic bone biology, disease, diagnosis, prevention, surgery, and treatment modalities (ARONJ)

    Bisphosphonates (Alendronate, Zolendronate, Pamidronate and others) and additional anti-osteoclastic drugs such as RANKL inhibitors (Denosumab) are among the most prescribed drugs in the world today.

    26 million prescriptions for Alendronate in the US alone are used for treatment of postmenopausal osteoporosis and 250,000 patients with metastatic bone cancer are treated with high dose intravenous bisphosphonates.

    These drugs have been noted to have profound influences on oral and orthopedic health including exacerbation of dental diseases, osteonecrosis of the jaw requiring ablation, spiral fractures of the femur, bone pain, and spinal and other foramenal stenosis These medications have also been associated with a marked decrease in femoral neck fractures, compression fractures of the spine and other osteoporotic fractures such as wrist and humerus.

    Past call: 2016

  • Bisphosphonate-induced Osteonecrosis of the Jaws (BRONJ)
    Bisphosphonate treatment induces cell death in osteoclast populations, slowing bone loss in osteoporosis and impeding the spread of certain cancers (bone metastases), but is also associated with an increased risk of osteonecrosis of the jaw, especially when combined with dental surgery. Bisphosphonate treatment may be received intravenously (94% of BRONJ cases) or orally (6%). These osteonecrotic symptoms have only been observed in the craniofacial region, probably because the local turnover of bone is relatively high; anything that inhibits this normal function will be especially pronounced here.

    Past call: 2011
  • Bone regeneration using tissue engineering and CAD-CAM techonolgy: Their impact on facial bone reconstruction

    Ablative surgery or major facial trauma in the maxillofacial area leads to bone defects that predispose functional as well as aesthetic complications. The bone defects of the facial skeleton need immediate reconstruction to provide satisfactory function of the jaws as well as an acceptable aesthetic outcome. 
    Reconstruction of the maxillofacial area with composite microvascular flaps is challenging and needs a team with experienced surgeons. The surgery is time consuming not only because of the microvascular procedures themselves, but due to demand for optimize intraoperatively the configuration and symmetry of the facial skeleton.

    The development of three-dimensional (3D) computerized modelling in medicine has been rapid during the last years. However, the use of above mentioned CAD-CAM (computer aided design and manufacturing) is still limited. The technology gives tools for surgeons to plan and to train virtually for the surgery, to design, and manufacture the implants needed for the surgery.

    Bone tissue engineering requires several constructive factors. These include among others biocompatible scaffolds and matrices, cells, osteo- and angioinductive growth factors. Modern 3D CAD-CAM technology enables patient-specific scaffold and matrix manufacturing. The scaffold, matrix or implant temporarily replaces the missing part of jaw and allows cells to generate bone accordingly leading to anatomic and symmetrical restoration. Increasing number of studies, both experimental and clinical, are available that show bone regeneration in facial bone defects using CAD-CAM technology, patient-specific matrices and cells.

    Current call: 2016 

  • Large Bone Defects
    Large bone defects can complicate osteosynthesis and may lead to fracture nonunion. This project supports effective, innovative solutions to this familiar problem in orthopedic surgery. Current efforts include both in vitro (progenitor cells, vascularization, scaffolds) and in situ (autologous grafts, genetic manipulation, delivery vehicle) approaches.

    Critical size bone defects in relation to CranioMaxilloFacial surgery
    (ordered by titles)

    A novel bioactive multifunctional dendrimer-cell bone scaffold for polytraumatic large bone defects
    Sauerbier S / Mata A / Freimann T / Duttenhoefer F / Eglin D / Niemeyer P
    University Medical Center, Freiburg (Germany) 
    Project #: C-10-60S 
    Project description: link to PDF file

    Biodegradable inductive load-bearing bone regeneration scaffold
    Jabbari E / Markwald R / Carnevale K / Sharawy M
    University of South Carolina, Columbia (USA) 
    Project #: C-10-44J 
    Project description: link to PDF file

    Hydrogel-titanium composites for mandibular reconstruction
    Weber F / Grätz K / de Wild M / Kruse A / Bredell M
    University Hospital Zurich (Switzerland) 
    Project #: C-10-37W 
    Project description: link to PDF file

    Optimizing neovascularization of biomimetic implants for repair of large craniofacial defects
    Warren S / Davidson E / Knobel D / Butala P / Sutan S / Crawford J
    New York University (USA) 
    Project #: C-10-45W 
    Project description: link to PDF file

    Osteogenic effect of neonatal dura on critical sized defects
    Gosain A / Cooper G
    Case Western Reserve University, Cleveland (USA) 
    Project #: C-10-59 G 
    Project description: link to PDF file

    Phospholipid delivery for cell-based approaches to treat critical-sized craniofacial bone defects
    Leach K / Karin N
    University of California, Davis (USA)
    Project #: C-10-39L
    Project description: link to PDF file

    Regeneration of a critical size mandibular defect by using an innovative bone engineering strategy
    Hutmacher D / Lynham A / Saifzadeh S / Schuetz M / Rohner D
    Queensland University of Technology, Kelvin Grove (Australia)
    Project #: C-10-61H
    Project description: link to PDF file
  • CPP Imaging and Planning in Surgery

    This widely inclusive research initiative is devoted to imaging and planning in all stages of surgery: pre-operative, intra-operative, and post-operative management. The AOCMF research guide provides a state-of-the-field overview for everything from CT-based surgical simulations to custom implant design. 

    2012 (ordered by title)

    An occlusion simulation system during virtual surgery based on collision and mesh editing
    Liu X / Zhang X  /Wang X / Li C / Peng Y
    Peking University (China)
    Project #: C-12-19L
    Project description (PDF)

    Development of a 3-D software for an all-in-one-planning-solution of orthognatic surgical procedures
    Rana M / Essig H / Tavassol F
    Medical School Hannover (Germany)
    Project #: C-12-21R
    Project description (PDF)
    Workflow for improving 2-D and 3-D skull visualization - a novel iterative voxel/mesh based approach
    Kamer L /  Noser H
    AO Research Institute Davos (Switzerland)
    Project # C-12-12K
    Project description (PDF)


    2010 (ordered by title)

    3-D characterization of facial deformities and prediction of facial soft and hard tissue response to orthognatic surgery

    Cheung L / Jayaratne Y / Zwahlen R / Lo J / Chua H / Choi YK
    University of Hong Kong (China) 
    Project #: C-10-16C 
    Project description (PDF)

    Clinical accuracy in maxillo-mandibular reconstruction using fibula flap: virtual vs stereomodel
    Lo J / Peng Y / Cheung L / Jayaratne Y
    University of Hong Kong (China) 
    Project #: C-10-20L 
    Project description (PDF)

    Evaluation of accuracy of CAD/CAM fabricated splints for orthognathic surgery
    Zizelmann C / Hammer B / Rohner D / Kokemüller H / Noser H / Kamer L
    Hirslanden Medical Center, Aarau (Switzerland) 
    Project #: C-10-25Z 
    Project description (PDF)

    Prediction of soft tissue changes in bimaxillary surgery for obstructive sleep apnea
    Salisbury K / Girod S
    Stanford University, Palo Alto (USA) 
    Project #: C-10-30S 
    Project description (PDF)

    Rapid prototyped individual orbital wall implant
    Process description of individual orbital wall reconstruction using 3-D CAD – Rapid prototyping (RP) techniques
    Kontio R / Westermark A / Suomalainen A 
    Helsinki University Hospital (Finland) 
    Project #: C-10-1K 
    Project description (PDF)

    Realtime-navigated, customized correction of superior sulcus deformity and enophthalmos in anophthalmic patients using computer-assisted designed 3D titanium-meshes
    Rana M / Essig H / Gladilin E / Zizelmann C / Schramm A / Gellrich NC / Kokemüller H / Wilde F
    Medical School Hannover (Germany) 
    Project #: C-10-17R
    Project description (PDF)

    Workflow for custom-made CAD/CAM titanium plates based on virtually planned maxillofacial reconstruction
    Rohner D / Kamer L / Noser H / Zizelmann C / Hammer B
    Hirslanden Medical Center, Aarau (Switzerland) 
    Project #: C-10-22R 
    Project description (PDF)


    2009 (ordered by title)

    3-D reconstruction of the orbita from 3T MRI as an alternative to CT

    Schmutz B / Coulthard A / Rahmel B / Schütz M
    Queensland University of Technology (Brisbane, Australia) 
    Project #: C-09-3S 
    Project description (PDF)

    3-D statistical skull and face model: development and application in the design and outcome analysis of craniofacial surgery 
    Antonyshyn O / Mainprize J
    University of Toronto (Canada)
    Project #: C-09-6A 
    Project description (PDF)

    Black bone MRI in the diagnosis and planning of craniofacial, orthognathic and mandibular oncological surgery
    Watt-Smith S / Eley K / Golding S
    University of Oxford & Radcliffe Hospitals NHS Trust (Oxford / Great Britain) 
    Project #: C-09-1W 
    Project description (PDF)

    CT analysis of structural buttresses in the traumatized nose – A basis for decision making for early open rhinoplasty and biomechanical study of nasal structural support
    Lee S / Lee HP / Leow WK / Shim TWH / Yeo M
    National University of Singapore 
    Project #: C-09-2L
    Project description (PDF)

    Multimodal virtual model for computer-assisted complex reconstruction of the midfacial deformities
    Essig H / Winkelbach S / Kokemüller H / Tavassol F / Rücker M / Shin H / Gellrich NC
    Hannover Medical School (Germany)
    Project #: C-09-4E 
    Project description (PDF)